New
research published in The Journal of Physiology identifies a novel protein that
reduces the likelihood of obesity and related metabolic disorders in boys.
It
is well-known that unhealthy parental lifestyles and health conditions
including obesity (particularly from the mothers) are linked to an increased
risk of obesity, diabetes and other metabolic disorders in children. However,
the underlying mechanism has not been clearly understood.
This
new research focuses on the protein SIRT1, which is an important regulator of
metabolism and stress responses. The bulk of previous studies suggest that
SIRT1 plays important roles in age-related diseases. This new finding links the
development of childhood metabolic disorders in males due to obesity in mothers
to reduced SIRT1 levels in these offspring. In other words, when the level of
SIRT1 is increased in the male offspring, excessive weight gain is halted,
blood sugar regulation is improved, and the levels of fat in the blood and
liver of these offspring are reduced.
The
research conducted by University of Sydney and University of Technology Sydney
involved breeding females on a high fat diet with male mice
genetically-modified to have an additional SIRT1 gene. Male offspring were
either normal or had increased levels of SIRT1. These pups were then examined
for signs of developing metabolic diseases.
Dr.
Long The Nguyen, first author on the study, commented on the findings:
"Gestational
weight control and current therapeutic practices are ineffective in preventing
the effects of maternal obesity on the next generation. Our study provides
evidence of SIRT1 countering metabolic disorders in offspring of mothers on
high fat diets, making it a promising therapeutic target in humans."
Further
studies involving an investigation of the offspring in adulthood, and also
their children, are being conducted to understand the prolonged and
intergenerational effects of SIRT1 therapy.
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