Tuesday, 20 November 2018

Yokohama Streetcar Museum displays street car vehicles that ran throughout the Yokohama City for nearly 70 years, model trains and photographs. A large diorama where visitors can move model trains and a simulator of subway operation are also popular attractions.

The Museum has under gone a renovation, and it's renewal opening was on Jan. 28th, 2017. Yokohama Streetcar Museum displays street car vehicles that ran throughout the Yokohama City for nearly 70 years, model trains and photographs. A large diorama where visitors can move model trains and a simulator of subway operation are also popular attractions.

Directions: Yokohama Municipal Tramway Museum is near JR Negishi station on the Negishi Line, about a 10-minute ride from Yokohama by a Keihin-Tohoku through service train. From Negishi station, take a bus on route #21/#78 to Shiden-Hozonkan, the end of the service. It will be about a 7-minute bus ride.

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Thursday, 1 November 2018

New research published in The Journal of Physiology identifies a novel protein that reduces the likelihood of obesity and related metabolic disorders in boys.
It is well-known that unhealthy parental lifestyles and health conditions including obesity (particularly from the mothers) are linked to an increased risk of obesity, diabetes and other metabolic disorders in children. However, the underlying mechanism has not been clearly understood.
This new research focuses on the protein SIRT1, which is an important regulator of metabolism and stress responses. The bulk of previous studies suggest that SIRT1 plays important roles in age-related diseases. This new finding links the development of childhood metabolic disorders in males due to obesity in mothers to reduced SIRT1 levels in these offspring. In other words, when the level of SIRT1 is increased in the male offspring, excessive weight gain is halted, blood sugar regulation is improved, and the levels of fat in the blood and liver of these offspring are reduced.

The research conducted by University of Sydney and University of Technology Sydney involved breeding females on a high fat diet with male mice genetically-modified to have an additional SIRT1 gene. Male offspring were either normal or had increased levels of SIRT1. These pups were then examined for signs of developing metabolic diseases.
Dr. Long The Nguyen, first author on the study, commented on the findings:
"Gestational weight control and current therapeutic practices are ineffective in preventing the effects of maternal obesity on the next generation. Our study provides evidence of SIRT1 countering metabolic disorders in offspring of mothers on high fat diets, making it a promising therapeutic target in humans."

Further studies involving an investigation of the offspring in adulthood, and also their children, are being conducted to understand the prolonged and intergenerational effects of SIRT1 therapy.

Abstract submission: Click Here

Monday, 29 October 2018

Yokohama Bay Bridge is the best suspension bridge in Japan that is around 860 m in length opened
for traffic and visitors in 1989. Yokohama Bay Bridge is constructed as a necessary transportation route of the port bodily distribution which connects Yokohama to Tokyo and serves as a bridge of the 2-layer kind which connects Daikoku Futo in Yokohama to pastureland division.

Yokohama Bay Bridge serves as a bridge of the 2-layer kind which connects this Daikoku Futo in Yokohama to pastureland division. By National Route 357, the higher ranges even have PA by a metropolitan high-pace alongside the bay line, and a lower layer part has it within the Daikoku Futo side. 
From right here, there’s a promenade “Yokohama skywalk” alongside which he can stroll underneath the bridge pier of Yokohama Bay Bridge.

Furthermore, there’s additionally a parking area at Yokohama Bay Bridge, and it is also a time-tested dating spot. Yokohama Bay Bridge is used additionally for a lot of movies or the stage of TV from the peak of the notability the “metropolitan quantity battle 01”. “Godzilla Mosul king Gondola giant monster all-out attack”, sequences “prison harmful” and many others.

Yokohama Bay Bridge contains a promenade for pedestrian visitors referred to as Sky Walk. From 50 to 60 meters above the water it gives views of the bay and Minto Mirai.
The heavy truck traffic on the bridge simply beside the walkway generally is a little bit of a distraction. The walkway is roofed and is wheelchair accessible.

The Yokohama Bay Bridge in Yokohama is a masterpiece and touted for being the “Gateway to the Port of Yokohama”, due to its potential of having the ability to mix usefulness with architectural magnificence. Yokohama Bay Bridge is a good site from just about any edge. This is exceptionally fascinating because the extension was fabricated to resist the stable tremor that’s fundamental in Yokohama.

ConnectsHonmoku and Daikoku
The Yokohama Bay Bridge completed in 1989; this 860-meter suspension extension connects the 2 wharfs of Honmoku and Daikoku. In case you are fascinated by nice architectural and engineering designs, you ought to not miss the Yokohama Bay Bridge! It’s a class above, among the best seen around the globe! Don’t forget to bring your camera with you and take a lot of photos from different angles!

The Yokohama Bridge has a double-deck truss superstructure with six car lanes on the highest and backside decks.  The bridge has fifty-five m (a hundred and eighty ft) vertical clearance to permit large container and cruise ships entry into Yokohama Harbor. The suspension cables have a fan association between the towers and the girders. The primary span is 460 m length and the fact spans are 200 m. As a result of this space has large earthquakes, the bridge was designed to permit the heavy superstructure to maneuver out of the section with the towers throughout robust shaking.

Book Your travel To Yokohama Now: Click Here

Wednesday, 3 October 2018

Yokohama Chinatown is the largest Chinese town in Japan. With it gorgeous temple and traditional gates guarding the four directions, it is a fascinating sightseeing spot. Moreover, unique cuisine and gorgeous souvenirs make the Chinatown a must visit place
Craving Chinese cuisine while visiting Japan? Or you happen to be around Tokyo, wondering what to do next? There is no better place to visit than the Chinatown in Yokohama, also known as Yokohama Chukagai. It is the largest one in Japan and a must visit for its fabulous food, sightseeing spots and lively atmosphere. The hustle bustle and the vibrant vibe of this place will surely make you want to visit again. 
Yokohama Chinatown developed after the port of Yokohama was opened to foreign trade in 1859. It became the residence area of the many Chinese traders who settled down in the city. There are more than 600 Chinese stores and restaurants in the Chinatown, buzzing with activity from morning until late in the night

Four colorful gates named after the four directions in Chinese tradition stand as entrances to Chinatown and five more gates can be found within. You can enter the town from any of the four gates. Guardian deities are enshrined in each of these gates, according to the principles of Feng Shui. It is believed that these deities protect the trade and prosperity of the Chinatown.
The East Gate (Chōyō-mon) relates to the Azure Dragon God, and brings prosperity. The South Gate (Suzaku-mon) is associated with Suzaku - the sacred Vermillion Bird - and hence the color red. It brings good fortune and protection from disaster. The North Gate (Genbu-mon) relates to the Black Tortoise, and is associated with the God Xuanwu (in Chinese) or Genbu (in Japanese). The West Gate (Enpei-mon) is related to the White Tiger deity of Chinese mythology, and is known as Baihu (in Chinese) or Byakkō (in Japanese). The gate relates to eternal peace.
The fifth gate, Zenrin-mon, also known as "the Gate of Good Neighborly Relations" is the symbol of Chinatown and the most beautiful, with its bright red color. It symbolizes warm human relationships and the act of welcoming everyone with an open heart.

This bright red colored temple is located in the center of Chinatown. Built in 1873 by the Chinese residents, it is dedicated to the Chinese deity of good business and prosperity.
The temple is so exquisite and peaceful that one cannot escape its charm. Visitors can offer prayers and also light incense sticks in front of the temple. During the night, the temple is lit up by lanterns and the view is simply blissful Kanteibyo Temple is elaborately decorated with beautiful and intricate patterns, offering one of the best photographic views in the area.

One of the finest attractions of the Yokohama Chinatown is the cuisine offered at its many restaurants and food stands. Visitors can spend big on a single meal or fill up on steamed buns for a single coin. There is a choice for all tastes and budgets.
You will notice the street side hawkers selling large steamed buns. It is hard to resist these aromatic and delicious steamed buns which are available at a very cheap price. Filled with various ingredients, these massive and well-loved snacks abound the streets of Chinatown. I especially recommend the huge steamed pork buns, loaded with coarsely chopped meat, gao-wa (leeks), and tiny cubes of pickled mustard green. Particularly popular are the goma-dango (sesame balls), small fried balls with a red bean mixture inside. Shouronpo are another popular treat for non-vegetarians, containing a meat based filling. They are so delicious that you will want to try all the varieties.

Mābōdōfu is another must try dish from Chinatown. Originally a dish from the Sichuan province in China, it consists of tōfu boiled in a spicy chili- and red bean based sauce cooked with fermented black beans and minced meat which is often pork or beef. 
Variations are made with other ingredients popular in Japan. Mābōdōfu comes in a set meal and is affordable. Many restaurants have different prices for the same dish. You can choose from the array of restaurants along the streets of Chinatown. A picture of the menu and the prices of each dish are displayed on the boards outside the shops, so choosing what and where you want to eat won't be a difficult task.

Chinatown boasts a variety of shops selling Chinese vegetables, fruit, herbs, seasonings and spices. In addition, one can find Chinese medicine stores, select tea shops, as well as stores selling kitchen utensils, lanterns and Chinese wines. The stalls of Chinese fortune tellers, palm readers and astrology advisers are also an usual sight on the streets in the area.
The best keepsake from this vibrant town would be, for example, good luck charms or the charming traditional Chinese dress called "qipao". The qipao is very hard to find in other areas of Japan. Souvenirs from the store "Panda memorabilia" are also great. This shop features accessories, sweets and stationery items inspired by the cuteness of the panda.

In Conclusion
YokohamaChinatown is a fascinating area that will allow you to feel as if you are traveling to Japan and China at the same time. It is a great destination for a peaceful afternoon and I warmly recommend it as a place that symbolizes the multicultural appeal of Yokohama.

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Saturday, 29 September 2018

Obesity affects the cardiovascular system in multiple ways. Obese individuals have an increased total blood volume to meet the perfusion needs of the increased adipose tissue. Cardiac and stroke work indices remain normal in normotensive obese individuals. The increase in cardiac output is also accompanied by a decrease in systemic vascular resistance in normotensive obese individuals. Because of increased LV workload, oxygen consumption is also increased; the oxygen consumption increases linearly with the increase in body weight. 

Health service use and medical costs associated with obesity and related diseases have risen dramatically and are expected to continue to rise. Besides an altered metabolic profile, a variety of adaptations/alterations in cardiac structure and function occur in the individual as adipose tissue accumulates in excess amounts, even in the absence of comorbidities. Hence, obesity may affect the heart through its influence on known risk factors such as dyslipidemia, hypertension, glucose intolerance, inflammatory markers, obstructive sleep apnea/hypoventilation, and the prothrombotic state, in addition to as-yet-unrecognized mechanisms.
On the whole, overweight and obesity predispose to or are associated with numerous cardiac complications such as coronary heart disease, heart failure. Currently, nearly 70% of adults are classified as either overweight or obese as compared with fewer than 40% just 40 years ago. One can argue about the impact of overweight and mild obesity on overall prognosis particularly without accounting for levels of cardiorespiratory fitness (fitness). Nevertheless, very recent high-profile data have suggested obesity may account for nearly 20% of overall mortality.

Obesity can interfere with this process by contributing to cardiovascular disease risk factors such as high blood pressure and diabetes. However, it also can harm the heart muscle more directly.  When a person is obese, that person’s volume of circulating blood goes up. This means that the heart has to pump a greater volume of blood with each heartbeat, which puts strain on the heart over time. Additionally, the heartbeat is governed by a series of electrical impulses in the heart muscle. Obesity certainly increases total blood volume, stroke volume, and cardiac output, so typically, systemic vascular resistance in obesity is reduced for any given level of blood pressure. 
Although most of the increases in cardiac output in obesity are due to high stroke volume (because heart rate is typically not increased), occasionally, heart rate may be slightly increased as a result of increased activation of the sympathetic nervous system. obesity is often shifted to the left as a result of increases in filling pressure and volume, which increases CV work, also leading to left ventricular (LV) changes with dilation and LV hypertrophy. The good news is that even modest weight loss can reduce cardiovascular risk factors and improve heart health. Anyone who wishes to begin a weight loss program should discuss options with his or her physician.

     Obesity and Coronary Heart Disease
     Cardiovascular Impact Adipose Tissue
     Congestive Heart Failure
     Treatment of Obesity and Heart Disease
     Weight Control Reduce heart disease
     Heart Disease
     Obesity and risk of chronic diseases development
    Obesity, Asthma & Allergies: the Inflammatory Connection

Abstract Submission: https://obesity.conferenceseries.com/asiapacific/abstract-submission.php

Thursday, 20 September 2018

Pediatric or teens weight troubles is the most commonplace nutritional sickness among kids and youngsters worldwide, The occurrence of obesity is maximum among particular ethnic organizations. Obesity will increase the risk of coronary heart diseases in kids and adults. Obesity in childhood causes hypertension, dyslipidemia, chronic inflammation, multiplied blood clotting tendency, endothelial disorder, and hyperinsulinemia and reasons reproductive disorder in adults. The prevention of pediatric obesity via selling healthy eating plan, interest, and surroundings must be a primary intention, as attaining effective, prolonged-lasting outcomes with life-style amendment once weight problems takes region is difficult. 
Childhood Obesity could be a medical disorder that influences children and youngsters. Everybody features a body shape that's fair right for him or her changes but in some cases we will store pointless body fat. Most childhood unfortunate weights are caused by children eating as well much and not working out sufficient. A complex and association framework of components contributes to expanding rates of overweight and corpulence – natural, behavioral, social, mental, mechanical, natural, financial and social – working at all levels from the person to the family to society as a entirety. Cases of these variables incorporate more inactive “screen time” for children, need of get to physical activity openings, the promoting of nourishments and refreshments tall in fat, sugar and/or sodium to children and expanded junk-food accessibility and expanding parcel sizes. Children become to be overweight and corpulent for an assortment of reasons. 
The foremost common causes are hereditary components, need of physical action, unfortunate eating designs, or a combination of these components. Analysts have recognized two hereditary varieties that show up to extend the chance of childhood obesity. The ponder creators took information from North American, Australian and European meta-analysis of 14 considers comprising of 5,530 stout children and 8,318 non-obese kids. 
The relationship between obesity in children and a parent’s part has an irrefutable association. It is consequently accepted children spend most of their early life within the company of their family, subsequently, appropriate weight improvement depends on propensities displayed at domestic.

•   Causes of childhood obesity
•   Symptoms and complications of obesity
•   Genetic, behavioral and environmental factors of obesity
•   Convenience foods and obesity
•   Prevention and treatment of pediatricobesity
•   Pharmacological and surgical treatment of pediatric obesity

Monday, 17 September 2018

Visiting spots in Yokohama: Yokohama Kwan Teibyo

The Kwan Tai Temple enshrines Kwan Tai, a general of Shu Kingdom who served under the warload Liu Bei in the period of the three kingdoms(AC220-280) in China,  He is known as a man of war, bravery and righteousness and worshiped throughout China, especially in Southern part of China. Many Chinese from Canton came to Yokohama as office clerks for Western trading companies, tailors, barbers, and chefs and formed the largest community in Japan.

They built the temple in 1871. It has been the center of the community since then.  It is located at the corner of Chusan Ro and Kan Tei Byo street. The temple was destroyed by fires three times in the past. The current temple is the 4th one. The temple is known as  Kan Tei Byo in Japanese and loved by local people,too. It is also one of Yokohama's tourist places now.

Because of his characters and skills in logistics- he is believed to have invented an Abacus and a Chinese book keeping-   the temple is worshiped by merchants. Besides prosperity in businesses, it is believed to have benefits such as health, safety, well-being of family, etc, and the temple is visited throughout the year.

Some years ago, a famous Feng-shui practitioner introduced the temple as a cosmic place, where you can be given mystical power by visiting in his books. I do not believe in superstitions. But I feel as though I got energized after visit. Maybe that is the center of the town where is full of vivid color, lively sounds and delicious food.

Visit this amazing place in Yokohama; plan your trip to Japan.
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